The Graphene Antibacterial Mechanism ndi Kugwiritsa Ntchito

Mphuno ya m'kamwa ndi microecosystem yovuta yomwe ili ndi mitundu yopitilira 23,000 ya mabakiteriya omwe amamuzungulira.Nthawi zina, mabakiteriyawa amatha kuyambitsa matenda amkamwa komanso kukhudza thanzi lonse. Komabe, kugwiritsa ntchito mankhwala opha maantibayotiki kumabweretsa zovuta zosiyanasiyana, kuphatikiza kuwonongeka kwamankhwala mwachangu, kumasulidwa, komanso kukula kwa kukana kwa ma antibiotic. M'zaka zaposachedwa, kafukufuku wasintha kwambiri pakupanga zida zophatikizika zokhala ndi antimicrobial properties pogwiritsa ntchito nanomatadium. Pakadali pano, zida za nanosilver ion-based antibacterial ndi graphene-based antibacterial zida zimagwiritsidwa ntchito kwambiri pamsika.M'nkhaniyi, tikambirana za graphene antibacterial limagwirira ndi kugwiritsa ntchito mumsuwachi.

 

Graphene ndi mbali ziwiri za kaboni nanomaterial wopangidwa ndi maatomu a kaboni opangidwa mu latisi ya hexagonal yokhala ndi sp2 hybridized orbitals.Zotuluka zake zimaphatikizapo graphene (G), graphene oxide (GO), ndi kuchepetsedwa kwa graphene oxide (rGO). Amakhala ndi mawonekedwe apadera amitundu itatu komanso akuthwa m'mphepete mwake.Research yawonetsa antibacterial properties ndi biocompatibility ya graphene komanso zotumphukira zake. Kuphatikiza apo, amagwira ntchito ngati zonyamulira zabwino za antimicrobial agents, zomwe zimawapangitsa kukhala odalirika pakugwiritsa ntchito mosiyanasiyana m'minda yamankhwala amkamwa.

Ubwino wagraphene antibacterial zipangizo

1. Chitetezo ndi Ubwenzi Wachilengedwe, Wopanda Poizoni: Kugwiritsa ntchito nthawi yayitali kwa nanosilver kumatha kubweretsa nkhawa zachitetezo chifukwakudzikundikira zotheka ndi kusamuka. Siliva yochulukirachulukira ikhoza kukhala yovulaza kwambiri kwa anthu ndi nyama zoyamwitsa, chifukwa imatha kulowa mitochondria, miluza, chiwindi, kayendedwe ka magazi, ndi mbali zina za thupi kudzera mu kupuma. Kafukufuku wawonetsa kuti tinthu tating'onoting'ono ta nanosilver timawonetsa kawopsedwe kwambiri poyerekeza ndi ma nanoparticles ena achitsulo monga aluminiyamu ndi golide. Chotsatira chake, European Union imasungabe kaimidwe kosamala pakugwiritsa ntchito zida za nanosilver antimicrobial.Motsutsana, zida za antimicrobial zochokera ku graphene zimagwiritsa ntchito njira zingapo zoletsa kulera, monga "mipeni ya nano." Amatha kuwononga kwathunthu ndikuletsa kukula kwa bakiteriyapopanda poizoni wa mankhwala. Zida izi zimaphatikizana mosasunthika ndi zida za polima, kuti zitsimikizirepalibe gulu lakuthupi kapena kusamuka. Kutetezedwa ndi kukhazikika kwa zinthu zopangidwa ndi graphene ndizotsimikizika. Mwachitsanzo, pakugwiritsa ntchito zinthu zomwe zimagwiritsidwa ntchito, mafilimu/matumba osungira zakudya a graphene-based PE (polyethylene) alandila ziphaso kuti azitsatira zakudya malinga ndi Regulation (EU) 2020/1245 ku European Union.
2. Kukhazikika Kwanthawi Yaitali: Zopangidwa ndi graphene zimawonetsa kukhazikika kwapamwamba komanso kukhazikika, kuperekaantimicrobial zotsatira zokhalitsa kwa zaka zopitilira 10. Izi zimatsimikizira kuti katundu wawo wa antimicrobial amakhalabe wothandiza pakanthawi yayitali, kuwapangitsa kukhala oyenera kugwiritsidwa ntchito kwanthawi yayitali pazinthu zaukhondo wamkamwa.
3. Biocompatibility ndi Chitetezo:Graphene, ngati zinthu ziwiri-dimensional carbon-based, amasonyeza kwambiri biocompatibility ndi chitetezo. Zimagwirizana ndi zinthu zosiyanasiyana zopangidwa ndi utomoni ndipo zimatha kugwiritsidwa ntchito mosamala pazinthu zosamalira pakamwa popanda kubweretsa zotsatirapo zoyipa pamatenda amkamwa kapena thanzi lonse.
4. Broad-Spectrum Activity:Zipangizo zopangidwa ndi graphene zimawonetsa ntchito zambiri zama antimicrobial,amatha kuloza mabakiteriya osiyanasiyana, kuphatikizapo mitundu yonse ya gram-positive ndi gram-negative. Iwo asonyezaantibacterial mitengo ya 99.9%motsutsana ndi Escherichia coli, Staphylococcus aureus, ndi Candida albicans. Izi zimapangitsa kuti zikhale zosunthika komanso zogwira ntchito m'matenda osiyanasiyana amkamwa.

 

The graphene antibacterial mechanism ndi motere:

Njira ya antibacterial ya grapheneyaphunziridwa mozama ndi gulu la mayiko osiyanasiyana. Kuphatikizapo ofufuza ochokera ku Chinese Academy of Sciences, IBM Watson Research Center, ndi Columbia University. Iwo apita patsogolo kwambiri pophunzira momwe ma cell amagwirira ntchito pakati pa graphene ndi nembanemba zama cell a bakiteriya. Mapepala aposachedwa pamutuwu adasindikizidwa m'magazini ya "Nature Nanotechnology."

Malinga ndi kafukufuku wa gululi, graphene imatha kusokoneza ma cell a bakiteriya, zomwe zimapangitsa kuti zinthu za intracellular ziwonongeke komanso kufa kwa bakiteriya. Kupeza uku kukuwonetsa kuti graphene ikhoza kukhala ngati "antibiotic" yosamva. Kafukufukuyu akuwonetsanso kuti graphene sikuti imangodzilowetsa m'maselo a bakiteriya, kuchititsa mabala, komanso imatulutsa mamolekyu a phospholipid mwachindunji kuchokera ku nembanemba, motero amasokoneza dongosolo la nembanemba ndikupha mabakiteriya. Kuyesa kwa ma electron microscopy kwapereka umboni wachindunji wazinthu zopanda kanthu m'maselo a bakiteriya atalumikizana ndi oxidized graphene, kuchirikiza kuwerengera kwamalingaliro. Chodabwitsa ichi cha kutulutsa kwa molekyulu ya lipid ndikusokonekera kwa membrane kumapereka njira yatsopano yama cell kuti mumvetsetse cytotoxicity ndi antibacterial zochita za nanomaterials. Ithandiziranso kafukufuku wopitilira pazachilengedwe za graphene nanomaterials ndikugwiritsa ntchito kwawo mu biomedicine.

 

Kugwiritsa ntchito kwa antibacterial graphene mumsika wamano:

 

Chifukwa chaubwino womwe uli pamwambapa wa zida zophatikizika za graphene, makina oletsa mabakiteriya a graphene ndi kugwiritsa ntchito kwawo kwakopa chidwi chachikulu kuchokera kwa ofufuza ndi akatswiri m'mafakitale ena.

Graphene antibacterial toothbush, yoyambitsidwa ndiGulu la MARBON, gwiritsani ntchito bristles zopangidwa mwapadera zopangidwa ndi zida za graphene nanocomposite. Chifukwa chake imatha kuletsa kukula ndi kubereka kwa mabakiteriya, potero kuchepetsa chiopsezo cha matenda amkamwa.

Ziphuphuzi ndi zofewa koma zolimba, zomwe zimapangitsa kuti mano ndi mkamwa azitsuka bwino komanso kuteteza enamel ndi chingamu. Msuwachi ulinso ndi chogwirira cha ergonomic chomwe chimapereka chogwira bwino komanso chosavuta kugwiritsa ntchito.

Tikukhulupirira kuti burashi ya antibacterial iyi ipereka chisamaliro chapadera chapakamwa. Ikhoza kuchotsa bwino zolembera za mano ndi zinyalala za chakudya. Kuphatikiza apo, imapereka chitetezo chokhalitsa cha antibacterial, kuonetsetsa kuti m'kamwa mwanu mumakhala mwatsopano komanso wathanzi.

 

 

Mapeto:

Graphene antibacterial toothbrush ikuyimira kupita patsogolo kwaposachedwa pakugwiritsa ntchito zida za graphene m'munda wa antibacterial. Ndi kuthekera kwawo kwakukulu, ma graphene antibacterial msuwachi akhazikitsidwa kuti asinthe chisamaliro chamkamwa, kupatsa anthu thanzi labwino komanso lomasuka. Pamene kafukufuku wazinthu za graphene akupita patsogolo, graphene antibacterial toothbrush itenga gawo lalikulu polimbikitsa thanzi la mkamwa ndikukhala bwino.